Piperazine → 4-Fluoro-2-(piperazin-1-yl)benzonitrile

Temperatur

90 °C

Tris(dibenzylideneacetone)dipalladium (0) (57.2 mg, 0.06 mmol) and rac-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (78 mg, 0.12 mmol) were added to a mixture of 2-bromo-4-fluorobenzonitrile (250 mg, 1.25 mmol), Cesium carbonate (611 mg, 1.87 mmol) and Piperazine (215 mg, 2.50 mmol) in dioxane (3 mL). Reaction vessel was placed in an oil bath at 90 °C 4pm. LCMS o/n shows several peaks. Larger peak corresponding to displacement of F by piperazine (MW266) than for desired product (205). Discarded

ORD-Eintrag

ord-91c1aa5c02fc46a586e9f5a373b7526a

Quelldatensatz

750 AstraZeneca ELN dataset

Originallink

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