Sodium Hydroxide → 5-Cyano-2-iodobenzoic acid

HRID 321998Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 321998
[OH-].[Na+].C[O:4][C:5](=[O:15])[C:6]1[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:7]=1[I:14]>O.CO>[I:14][C:7]1[CH:8]=[CH:9][C:10]([C:12]#[N:13])=[CH:11][C:6]=1[C:5]([OH:15])=[O:4]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 23076822Methyl 5-cyano-2-iodobenzoate

Produkt 1

HCID 220088225-Cyano-2-iodobenzoic acidAusbeute 66,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of sodium hydroxide (0.44 g, 11 mmol) in water (10 ml) was added to 2-iodo-5-cyanobenzoic acid methyl ester (2.7 g, 9.4 mmol) in methanol. The mixture was stirred for 20 h, then most of the solvent was evaporated and the residue acidified with 2N hydrochloric acid. The resulting precipitate was filtered off and dried to give a white solid (1.7 g). MS (−CI) m/z 272 [M-H]+.

Aufarbeitung

  1. custommost of the solvent was evaporated
  2. filtrationThe resulting precipitate was filtered off
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d0e0c6c8931248808b8d7128df7ffa4f
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211189B1

Notizen zur Reaktion

Wird geladen…