Sulfuric Acid → n-(2,6-Dichloro-4-carboxyphenyl)-7-methoxy-2-(1-methylethyl)benzofuran-4-carboxamide

HRID 322034Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 322034
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([O:10]C)=[O:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][C:14]([C:16]1[CH:17]=[CH:18][C:19]([O:28][CH3:29])=[C:20]2[O:24][C:23]([CH:25]([CH3:27])[CH3:26])=[CH:22][C:21]=12)=[O:15].S(=O)(=O)(O)O>C(O)COCCO.[OH-].[Na+].O>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][C:14]([C:16]1[CH:17]=[CH:18][C:19]([O:28][CH3:29])=[C:20]2[O:24][C:23]([CH:25]([CH3:27])[CH3:26])=[CH:22][C:21]=12)=[O:15]

Komponenten

6

Edukt 2

HCID 1118Sulfuric AcidHCID 22009528n-(2,6-Dichloro-4-methoxycarbonylphenyl)-7-methoxy-2-(1-methylethyl)benzofuran-4-carboxamide

Produkt 1

HCID 22009534n-(2,6-Dichloro-4-carboxyphenyl)-7-methoxy-2-(1-methylethyl)benzofuran-4-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittel2×HCID 8117Diethylene GlycolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

3.7 g of N-(2,6-Dichloro-4-methoxycarbonylphenyl)-7-methoxy-2-(1-methylethyl)benzofuran-4-carboxamide are refluxed for 15 min. in 20 ml of diethylene glycol and 30 ml of water in which 0.41 g of caustic soda is dissolved. The solution is diluted with water and acidified to pH 2 using 2 N sulfuric acid. The product precipitates in this process. It is filtered off with suction on a suction filter, washed free of acid with water and dried in vacuo: m.p. 279° C.

Aufarbeitung

  1. customThe product precipitates in this process
  2. filtrationIt is filtered off with suction on a suction
  3. filtrationfilter
  4. washwashed free of acid with water
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7fd1b9e472fd42ef9f2819e08ce2b609
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211203B1

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