Nitric Acid → 4-Bromo-5-nitroveratrole

Temperatur

10 °C

A mixture of concentrated nitric acid (14 mL) and acetic acid (42 mL) was cooled to 10° C. while stirring, and then 4-bromo-1,2-dimethoxybenzene (2 g, 9.21 mmol) was gradually added to the stirred mixture. The reaction mixture was warmed to 15° C., and stirring was continued for 60 minutes. The reaction mixture was cooled to 0° C. and stirred while adding ice water, and then extraction was performed with ether. The obtained organic layer was neutralized with saturated aqueous solution of sodium hydrogencarbonate and potassium carbonate, and then washed with water. After drying the organic layer over anhydrous magnesium sulfate, the desiccant was filtered off and the filtrate was concentrated under reduced pressure. The obtained crude product was recrystallized from ethanol to give 2.09 g of the title compound as light yellow crystals.

1. temperatureThe reaction mixture was warmed to 15° C.
2. stirringstirring
3. temperatureThe reaction mixture was cooled to 0° C.
4. stirringstirred
5. extractionextraction
6. washwashed with water
7. dry with materialAfter drying the organic layer over anhydrous magnesium sulfate
8. filtrationthe desiccant was filtered off
9. concentrationthe filtrate was concentrated under reduced pressure
10. customThe obtained crude product
11. customwas recrystallized from ethanol

ORD-Eintrag

ord-bf8cc02735c04ae4ad8c8836b354019e

Quelldatensatz

uspto-grants-2008_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07425554B2