4-Methylmorpholine → Ethyl acetate ethanol ammonia

HRID 322498Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 322498
[O:1]=[C:2]1[CH:7](CCC2C=CC3CCCNC=3N=2)CCC[N:3]1[CH2:20][C:21]([OH:23])=[O:22].CN1CCO[CH2:27][CH2:26]1.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1>CC#N>[NH3:3].[CH3:7][CH2:2][OH:1].[CH3:26][CH2:27][O:23][C:21]([CH3:20])=[O:22]

Komponenten

5

Edukt 3

HCID 79724-MethylmorpholineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 22008800HCID 22008800, Verbindung

Produkt 1

HCID 86587043Ethyl acetate ethanol ammonia

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A stirred mixture of 1-8 (71 mg, 0.20 mmol), 1-9 (59 mg, 0.22 mmol) (Rico et al., J. Org. Chem., 1993, 58, 7948), NMM (88 μL, 0.8 mmol), and CH3CN (25 mL) was treated with BOP (97 mg, 0.22 mmol). After 24 h, the reaction mixture was concentrated to dryness, dissolved in EtOAc, and then washed with H2O, dried (MgSO4), and concentrated. Flash chromatography (silica, 10% (NH3/EtOH/EtOAc) gave 1-10 as a colorless gum.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated to dryness
  2. dissolutiondissolved in EtOAc
  3. washwashed with H2O
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6ed823079f2249778c51d799d559c2c1
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211184B1

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