Leucine methyl ester hydrochloride → N-[N-(Phenylacetyl)-L-alaninyl]-L-leucine Methyl Ester

HRID 322775

Reaktionsgleichung

Reaktionsgleichung von HRID 322775
[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:13]([OH:15])=O)[CH3:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:17][O:18][C:19](=[O:26])[C@H:20]([CH2:22][CH:23]([CH3:25])[CH3:24])[NH2:21]>>[CH3:17][O:18][C:19](=[O:26])[C@H:20]([CH2:22][CH:23]([CH3:25])[CH3:24])[NH:21][C:13](=[O:15])[C@H:11]([CH3:12])[NH:10][C:8](=[O:9])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

3

Edukt 2

HCID 2723695Leucine methyl ester hydrochlorideHCID 7004640N-(Phenylacetyl)-L-alanine

Produkt 1

HCID 9923756N-[N-(Phenylacetyl)-L-alaninyl]-L-leucine Methyl Ester

Versuchsvorschrift

Following General Procedure A and using N-(phenylacetyl)-L-alanine (from Example B1 above) and L-leucine methyl ester hydrochloride (Aldrich), the title compound was prepared as a solid (mp=102.5-105° C.). The reaction was monitored by tlc (Rf=0.25 in 50% EtOAc/hexanes).

Quellen und Nachweise

ORD-Eintrag
ord-7ff7abca63b649faafc14b1b9903e598
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211235B1

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