Water → N,N'-Dicyclohexylurea

HRID 32339

Reaktionsgleichung

Reaktionsgleichung von HRID 32339
[CH:1]1([N:7]=[C:8]=[N:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH2:16]>CN(C=O)C>[C:8]([NH:7][CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1)([NH:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)=[O:16]

Komponenten

4

Edukt 2

HCID 962WaterHCID 10868Dicyclohexylcarbodiimide

Produkt 1

HCID 4277N,N'-Dicyclohexylurea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
4 °C

Versuchsvorschrift

To N-TeocT4 (0.017 g, 17 μmol) in 1 mL dry DMF was added dicyclohexylcarbodiimide (0.004 g, 18 μmol). After stirring for 30 minutes N-dimethyl-4-aminopyridine (0.004 g, 36 μmol) and Gly18 (0.017 g, 17 μmol) were added and the reaction stirred overnight. The cloudy solution was poured into 20 mL H2O and extracted twice with 10 mL CH2Cl2. The aqueous component was acidified to pH 3 with 1 N HCl and chilled to 4° C. The material was isolated by centrifugation and the pellet washed 3 times with 8 mL H2O. The pellet was dried in vacuum to yield dicyclohexylurea and N-TeocT4-Gly18. (SEQ ID NO: 6)

Aufarbeitung

  1. additionGly18 (0.017 g, 17 μmol) were added
  2. extractionextracted twice with 10 mL CH2Cl2
  3. customThe material was isolated by centrifugation
  4. washthe pellet washed 3 times with 8 mL H2O
  5. customThe pellet was dried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d889715e4eb84c7d91566f2edec9a1ef
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07427600B2

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