Reaktionsgleichung
[NH2:1][C@@H:2]([C:7]([OH:9])=[O:8])[C:3]([SH:6])([CH3:5])[CH3:4].O.O.O.O.O.O.O.O.[OH-].[Ba+2].[OH-].S(OC)(O[CH3:25])(=O)=O.S(=O)(=O)(O)O>>[CH3:25][S:6][C:3]([CH3:5])([CH3:4])[C@H:2]([C:7]([OH:9])=[O:8])[NH2:1]Komponenten
5
Versuchsvorschrift
A suspension of D-Penicillamine (10.0 g, 67.01 mmol) in 0.4N solution of barium hydroxide octahydrate (330 mL, 67.01 mmol) is chilled on an ice water bath. Dimethyl sulfate (6.6 mL, 70.36 mmol, 1.05 equiv) is added dropwise over a period of 30 minutes. The suspension stirred for 18 hours at room temperature. A solution of 1 N sulfuric acid is added to the solution (pH˜2) to precipitate out the barium sulfate. The supernatent is decanted and the precipitate is washed several times with water. The pH of the supernatent is adjusted to 6 with concentrated ammonium hydroxide and the water is evaporated off to give a pure white solid (10.9 g, 100% yield).
Aufarbeitung
- temperatureis chilled on an ice water bath
- customto precipitate out the barium sulfate
- customThe supernatent is decanted
- washthe precipitate is washed several times with water
- customthe water is evaporated off
Quellen und Nachweise
- ORD-Eintrag
- ord-04336a88bb094f4c96b11adc5567f5c6
- Quelldatensatz
- uspto-grants-2001_04
- Patentnummer
- US06218389B1
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