Hydrazine hydrate (1:1) → HCID 178507266, Verbindung

HRID 324569

Reaktionsgleichung

Reaktionsgleichung von HRID 324569
[CH:1]1([C:4](=O)[CH2:5][C:6]#[N:7])[CH2:3][CH2:2]1.O.[NH2:10][NH2:11]>C(O)C>[CH:1]1([C:4]2[CH:5]=[C:6]([NH2:7])[NH:11][N:10]=2)[CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 98127633-Cyclopropyl-3-oxopropanenitrile

Produkt 1

HCID 178507266HCID 178507266, VerbindungAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

5 g (0.046 mol) of 3cyclopropyl-3-oxo-propanenitrile were dissolved in 200 ml of ethanol and 2.26 ml (0.046 mol) of hydrazine hydrate were added. The solution was maintained at reflux for 5 hours and then the solvent evaporated under vacuum. The residue was re-dissolved with methylene chloride and washed several times with brine. The organic layer was dried over anhydrous sodium sulfate and the solvent evaporated to give 4.53 g (80% yield) of the title compound.

Aufarbeitung

  1. temperatureThe solution was maintained
  2. temperatureat reflux for 5 hours
  3. customthe solvent evaporated under vacuum
  4. dissolutionThe residue was re-dissolved with methylene chloride
  5. washwashed several times with brine
  6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  7. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-154fbe4b82e84bcda85fd24c5d81902f
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06218418B1

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