Dichloromethane → 2,3-Dihydrobenzofuran-5-carboxaldehyde

HRID 324605

Reaktionsgleichung

Reaktionsgleichung von HRID 324605
ClCCl.[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][CH2:5]1.[CH3:13][O:14]C(Cl)Cl>[Cl-].[Ti+4].[Cl-].[Cl-].[Cl-].O>[O:4]1[C:8]2[CH:9]=[CH:10][C:11]([CH:13]=[O:14])=[CH:12][C:7]=2[CH2:6][CH2:5]1

Komponenten

6

Edukt 3

HCID 6344DichloromethaneHCID 10329DihydrobenzofuranHCID 21004Methane, dichloromethoxy-

Produkt 1

HCID 7359012,3-Dihydrobenzofuran-5-carboxaldehydeAusbeute 61.555,602 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 160960Diamminetetrachlorotitanate(IV)KatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

Titanium chloride (28 ml) was dropwise added to a dichloromethane (100 ml) solution containing 2,3-dihydrobenzofuran (10.0 g, 83.2 mmols) and dichloromethyl methyl ether (11.3 ml, 0.125 mmols), while cooling with ice. The mixture was stirred for 1 hour, while still cooling with ice, and then water was added thereto. Dichloromethane was removed under reduced pressure, and the residue was extracted with ethyl acetate. The extract was washed with a saturated saline solution, then dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified through silica-gel chromatography (hexane/ethyl acetate=1/1) to obtain 11.4 g (yield: 92%) of the target compound. This was oily.

Aufarbeitung

  1. temperaturewhile cooling with ice
  2. temperaturewhile still cooling with ice
  3. customDichloromethane was removed under reduced pressure
  4. extractionthe residue was extracted with ethyl acetate
  5. washThe extract was washed with a saturated saline solution
  6. dry with materialdried with anhydrous magnesium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was purified through silica-gel chromatography (hexane/ethyl acetate=1/1)

Quellen und Nachweise

ORD-Eintrag
ord-e60d3f4560d94190a849d10d23a90938
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06218429B1

Verknüpfte Notizen

Wird geladen…