Phosphorus pentachloride → 4-Chloro-3-nitropyridine

HRID 324683

Reaktionsgleichung

Reaktionsgleichung von HRID 324683
O[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].P(Cl)(Cl)(Cl)(Cl)[Cl:12]>C(Cl)(Cl)Cl.C(O)C>[Cl:12][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9]

Komponenten

4

Edukt 2

HCID 24819Phosphorus pentachlorideHCID 178526806HCID 178526806, Verbindung

Produkt 1

HCID 27357814-Chloro-3-nitropyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21889567Chloroform ethanolLösungsmittel

Versuchsvorschrift

4-Chloro-3-nitropyridine was prepared from 4-hydroxy-3-nitropyridine(25 g, 0.179M), phosphorus pentachloride(40 g, 0.192M) and 1 mL of phosphorous oxytrichloride. The mixture was heated at 120° for 1 hour. The reaction mixture was diluted with chlorform/ethanol mixture(9/1) and the precipitate was filtered to afford desired. (mp. 153-154° C.)

Aufarbeitung

  1. temperatureThe mixture was heated at 120° for 1 hour
  2. filtrationwas filtered
  3. customto afford

Quellen und Nachweise

ORD-Eintrag
ord-6e835364453d44a4bcae929f8f059cf4
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06218539B1

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