HCID 178474238, Verbindung → HCID 178507147, Verbindung

HRID 32475

Reaktionsgleichung

Reaktionsgleichung von HRID 32475
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:16]([NH2:17])=[C:15]3[CH:18]=[CH:19][O:20][C:14]3=[N:13][CH2:12]2)=[CH:7][CH:6]=1)(=O)C>[OH-].[K+].CCO.O>[NH2:17][C:16]1[N:11]([C:8]2[CH:7]=[CH:6][C:5]([NH2:4])=[CH:10][CH:9]=2)[CH2:12][N:13]=[C:14]2[O:20][CH:19]=[CH:18][C:15]=12

Komponenten

5

Edukt 1

HCID 178474238HCID 178474238, Verbindung

Produkt 1

HCID 178507147HCID 178507147, VerbindungAusbeute 57,7 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittelHCID 14797Potassium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Compound 3-(4-acetamidophenyl)-4-aminofuro[2,3-d]pyrimidine 8 (242 mg) was dissolved in 2 M potassium hydroxide in the mixture of EtOH (16 mL) and water (4 mL). The mixture was heated (60° C.) for 24 h then concentrated in vacuo. Residual oil was triturated with cold water (6 mL) to give precipitation, which was filtrated, washed with water, and dried under the reduced pressure. The compound 9 (118 mg) as pale orange colored was obtained. MS(ES) m/e 227M+H].

Aufarbeitung

  1. concentrationthen concentrated in vacuo
  2. customResidual oil was triturated with cold water (6 mL)
  3. customto give
  4. customprecipitation, which
  5. filtrationwas filtrated
  6. washwashed with water
  7. customdried under the reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f06b98cc45974b1297cfbef9da28bc0b
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07427623B2

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