Ammonium Hydroxide → Diethyl 2,6-diisopropyl-4-(2-iodophenyl)pyridine-3,5-dicarboxylate

HRID 324860

Reaktionsgleichung

Reaktionsgleichung von HRID 324860
[I:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:10]([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])(=O)[CH:11]([CH3:13])[CH3:12].[OH-:21].[NH4+:22]>>[CH:11]([C:10]1[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:4]([C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[I:1])[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:21])=[C:10]([CH:11]([CH3:13])[CH3:12])[N:22]=1)([CH3:13])[CH3:12]

Komponenten

4

Edukt 3

HCID 14923Ammonium HydroxideHCID 81583Ethyl isobutyrylacetateHCID 6434392-Iodobenzaldehyde

Produkt 1

HCID 22005000Diethyl 2,6-diisopropyl-4-(2-iodophenyl)pyridine-3,5-dicarboxylate

Versuchsvorschrift

Prepared from 2-iodobenzaldehyde, ethyl isobutyrylacetate and concentrated ammonium hydroxide by the procedures described in Example 125, Steps A-B. 1H NMR (300 MHz, CDCl3): δ 0.94 (t, J=7.0 Hz, 6 H), 1.30 (d, J=6.6 Hz, 6 H), 1.34 (d, J=6.6 Hz, 6 H), 3.19 (septet, J=6.6 Hz, 2 H), 4.0 (q, J=7.0 Hz, 4 H), 7.0-7.40 (m, 3 H), 7.85 (m, 1 H).

Quellen und Nachweise

ORD-Eintrag
ord-83468a8fac5d4acab7545d0ef661031c
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06218431B1

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