Hydrochloric Acid → HCID 22001230, Verbindung

The title compound was prepared by dissolving the compound of Example 19, 2-(4-hydroxyphenyl)-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-6-hydroxybenzofuran, (3.1 g, 6.8 mmol) in 15 ml of methanol and treating with an excess of 3% hydrochloric acid in methanol. The volume was then reduced by boiling to 15 ml. Warm water (20 ml) was then added and the reaction mixture was further warmed to clarify. The reaction mixture was then filtered, followed by gradual cooling to 0° C., at which temperature the mixture was maintained for about one hour. The crystals, which had precipitated, were collected by filtration and washed with cold water. The pale yellow crystals were dried overnight, resulting in 2.82 g (84%) of the desired title product. mp 213-215° C.

1. customThe title compound was prepared
2. temperaturethe reaction mixture was further warmed to clarify
3. filtrationThe reaction mixture was then filtered
4. temperaturewas maintained for about one hour
5. customThe crystals, which had precipitated
6. filtrationwere collected by filtration
7. washwashed with cold water
8. customThe pale yellow crystals were dried overnight

ORD-Eintrag

ord-b135ca576f3e45c9b3a954aa95c3f8e9

Quelldatensatz

uspto-grants-2001_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06221838B1