Sodium methanethiolate → 6-Methyl-4-(methylthio)thieno[3,2-d]pyrimidine

HRID 32532Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 32532
[CH3:1][S-:2].[Na+].[CH3:4][C:5]1[S:13][C:12]2[C:11](Cl)=[N:10][CH:9]=[N:8][C:7]=2[CH:6]=1>C(#N)C>[CH3:4][C:5]1[S:13][C:12]2[C:11]([S:2][CH3:1])=[N:10][CH:9]=[N:8][C:7]=2[CH:6]=1

Komponenten

4

Edukt 2

HCID 4378561Sodium methanethiolateHCID 136832234-Chloro-6-methylthieno[3,2-d]pyrimidine

Produkt 1

HCID 179658316-Methyl-4-(methylthio)thieno[3,2-d]pyrimidineAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of sodium thiomethoxide (24S mg) and 6-methyl-4-chlorothieno[3,2-d]pyrimidine (Acta Pol. Pharm. (1986), 43(2), 97-100) (650 mg) in acetonitrile (50 mL) was stirred overnight. The mixture was filtered and the solid was washed with acetonitrile. The combined filtrate and washes were evaporated to give the title compound as a white solid (665 mg, 97%);

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. washthe solid was washed with acetonitrile
  3. customThe combined filtrate and washes were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-bfa91bba01444c858e262522dcf3c6d5
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07427616B2

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