3-Amino-1,2-propanediol → Methyl 3-[(2,3-dihydroxypropyl)amino]but-2-enoate

HRID 325879

Reaktionsgleichung

Reaktionsgleichung von HRID 325879
[CH3:1][O:2][C:3](=[O:7])[C:4]#[C:5][CH3:6].[OH:8][CH:9]([CH2:12][OH:13])[CH2:10][NH2:11]>C(O)C>[OH:8][CH:9]([CH2:12][OH:13])[CH2:10][NH:11][C:5]([CH3:6])=[CH:4][C:3]([O:2][CH3:1])=[O:7]

Komponenten

4

Edukt 2

HCID 735613-Amino-1,2-propanediolHCID 141019Methyl but-2-ynoate

Produkt 1

HCID 71430100Methyl 3-[(2,3-dihydroxypropyl)amino]but-2-enoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To 5.0 g (0.051 m) methyl-2-butynoate in 25 ml absolute ethanol is added 5.0 g (0.055 m) 2,3-dihydroxypropylamine. This solution is heated at 75°-80° for 18 hours and the solvent is then removed at reduced pressure. The residue oil is chromatographed on silica gel, eluting with 10% methanol/chloroform to afford the desired product as a white solid. m.p. 109°-111°. The yield is 5.6 g (59%). ##STR4##

Aufarbeitung

  1. temperatureThis solution is heated at 75°-80° for 18 hours
  2. customthe solvent is then removed at reduced pressure
  3. customThe residue oil is chromatographed on silica gel
  4. washeluting with 10% methanol/chloroform

Quellen und Nachweise

ORD-Eintrag
ord-54b41dbb78a644e4a0a8113df68008a9
Quelldatensatz
uspto-grants-1984_04
Patentnummer
US04443457

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