3-Amino-1,2-propanediol → Methyl 3-[(2,3-dihydroxypropyl)amino]but-2-enoate
Reaktionsgleichung
[CH3:1][O:2][C:3](=[O:7])[C:4]#[C:5][CH3:6].[OH:8][CH:9]([CH2:12][OH:13])[CH2:10][NH2:11]>C(O)C>[OH:8][CH:9]([CH2:12][OH:13])[CH2:10][NH:11][C:5]([CH3:6])=[CH:4][C:3]([O:2][CH3:1])=[O:7]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To 5.0 g (0.051 m) methyl-2-butynoate in 25 ml absolute ethanol is added 5.0 g (0.055 m) 2,3-dihydroxypropylamine. This solution is heated at 75°-80° for 18 hours and the solvent is then removed at reduced pressure. The residue oil is chromatographed on silica gel, eluting with 10% methanol/chloroform to afford the desired product as a white solid. m.p. 109°-111°. The yield is 5.6 g (59%). ##STR4##
Aufarbeitung
- temperatureThis solution is heated at 75°-80° for 18 hours
- customthe solvent is then removed at reduced pressure
- customThe residue oil is chromatographed on silica gel
- washeluting with 10% methanol/chloroform
Quellen und Nachweise
- ORD-Eintrag
- ord-54b41dbb78a644e4a0a8113df68008a9
- Quelldatensatz
- uspto-grants-1984_04
- Patentnummer
- US04443457
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