Water → AL 321

HRID 326158Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 326158
[CH3:1][C:2]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([CH3:21])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([S:18][C:19]#[N:20])[C:13](OCC)=[O:14])=[CH:7][CH:6]=1.[OH2:28]>C(O)C.Cl>[CH3:21][C:2]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)([CH3:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]2[S:18][C:19](=[O:28])[NH:20][C:13]2=[O:14])=[CH:7][CH:6]=1

Komponenten

5

Edukt 2

HCID 962WaterHCID 12830988HCID 12830988, Verbindung

Produkt 1

HCID 194620AL 321

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

1.9 g Of ethyl 3-[4-(2-methyl-2-phenylpropyloxy)phenyl]-2-thiocyanatopropionate is dissolved in 20 ml of ethanol and to the solution 20 ml of 6 N-hydrochloric acid is added. The mixture is refluxed for 24 hours. After cooling, water is added to the mixture. The mixture is subjected to extraction with ether. The extract is washed with water and then dried. After distilling off ether, the residure is crystallized from ether-n-hexane, whereby 730 mg of 5-[4-(2-methyl-2-phenylpropyloxy)benzyl]thiazolidine-2,4-dione is obtained.

Aufarbeitung

  1. additionis added
  2. temperatureThe mixture is refluxed for 24 hours
  3. temperatureAfter cooling
  4. extractionThe mixture is subjected to extraction with ether
  5. washThe extract is washed with water
  6. customdried
  7. distillationAfter distilling off ether
  8. customthe residure is crystallized from ether-n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-a86b4cd079d544eb80fcd767e2c89459
Quelldatensatz
uspto-grants-1984_04
Patentnummer
US04444779

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