Water → 4-{[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-4-phenyl-1H-imidazol-1-yl]methyl}cyclohexanone

HRID 32629Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 32629
O1[C:5]2([CH2:10][CH2:9][CH:8]([CH2:11][N:12]3[C:16]([C:17]4[S:18][C:19]5[N:20]=[CH:21][N:22]=[C:23]([NH2:26])[C:24]=5[N:25]=4)=[C:15]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[N:14]=[CH:13]3)[CH2:7][CH2:6]2)[O:4]CC1.O.C(O)(C(F)(F)F)=O>CC#N>[NH2:26][C:23]1[C:24]2[N:25]=[C:17]([C:16]3[N:12]([CH2:11][CH:8]4[CH2:9][CH2:10][C:5](=[O:4])[CH2:6][CH2:7]4)[CH:13]=[N:14][C:15]=3[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[S:18][C:19]=2[N:20]=[CH:21][N:22]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 10095197HCID 10095197, Verbindung

Produkt 1

HCID 100012704-{[5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-4-phenyl-1H-imidazol-1-yl]methyl}cyclohexanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

2-[1-(1,4-Dioxaspiro[4,5]dec-8-ylmethyl)-4-phenyl-1H-imidazol-5-yl][1,3]thiazolo[5,4-d]pyrimidin-7-amine (Example 178) (634 mg) was dissolved in MeCN (10 mL) and water (10 mL) and TFA (0.5 mL) was added. After 48 hours at ambient temperature, the title compound was obtained by preparative RPHPLC (eluting with a gradient of water and MeCN containing 0.1% TFA) as a colourless solid (570 mg, 99%);

Quellen und Nachweise

ORD-Eintrag
ord-3e7f4097845d4d9b8b6e0fd3192ac110
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07427616B2

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