Chloromethyl Methyl Ether → HCID 19932989, Verbindung

HRID 326466Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 326466
C(OC([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[N:10]=[CH:9]1)=O)(C)(C)C.[CH3:23][O:24][CH2:25]Cl.C(=O)([O-])O.[Na+]>C(#N)C>[C:19]([O:18][C:16]([NH:15][CH2:14][CH2:13][C:11]1[N:10]([CH2:23][O:24][CH3:25])[CH:9]=[N:8][CH:12]=1)=[O:17])([CH3:20])([CH3:21])[CH3:22]

Komponenten

5

Edukt 3

HCID 7864Chloromethyl Methyl EtherHCID 516892Sodium BicarbonateHCID 819122tert-butyl 4-{2-[(tert-butoxycarbonyl)amino]ethyl}-1H-imidazole-1-carboxylate

Produkt 1

HCID 19932989HCID 19932989, VerbindungAusbeute 84,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

1-t-Butoxycarbonyl-4-{2-(t-butoxycarbonyl-amino)ethyl}imidazole (78.1 g) is dissolved in acetonitrile (500 ml), and thereto is added methoxymethyl chloride (22.2 g), and the mixture is stirred at room temperature overnight. The reaction solution is poured into 10% aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The extract is washed, dried, and the solvent is distilled off to give 4-{2-(t-butoxycarbonyl-amino)ethyl]-3-methoxymethylimidazole (54.4 g) as oil.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe extract is washed
  3. customdried
  4. distillationthe solvent is distilled off

Quellen und Nachweise

ORD-Eintrag
ord-bea66919b5d84a29b23af46ad0ecc4d6
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05268377

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