Benzene, 1-(1-methylethenyl)-3-nitro- → 3-Isopropylaniline

HRID 326613

Reaktionsgleichung

Reaktionsgleichung von HRID 326613
[CH3:1][C:2]([C:4]1[CH:5]=[C:6]([N+:10]([O-])=O)[CH:7]=[CH:8][CH:9]=1)=[CH2:3].[H][H]>[Pd]>[CH3:1][CH:2]([C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[NH2:10])[CH3:3]

Komponenten

4

Edukt 2

HCID 6432621Benzene, 1-(1-methylethenyl)-3-nitro-HCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 4586793-IsopropylanilineAusbeute 78,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

Treatment of 3-nitroacetophenone (10 g) with methyltriphenyl phosphonium bromide (28 g) and n-butyllithium in hexane (78.4 mmol), as described in Example 1a, gave 3-(1-methylethenyl)nitrobenzene (9.5 g), δ (60 MHz, CDCl3) 2.1 (3H, s, CH3), 5.2 and 5.5 (2H, 2s, CH2), 7.2 to 8.2 (4H, m, ArH). Treatment of the above 3-(1-methylethenyl)nitrobenzene (9.5 g) with hydrogen and palladium on carbon (10%, 1.9 g) as described in Example 1a, gave 3-(1-methylethyl)aniline (6.15 g), δ (60 MHz, CDCl3) 1.1 (6H, d, (CH3)2), 2.6 (1H, m, CH) 3.4 (2H, bs, NH2) and 6.1 to 7.0 (4H, m, ArH).

Quellen und Nachweise

ORD-Eintrag
ord-6158aa0017284402999506bbe8a47de3
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05270309

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