4-Methoxybenzenesulfonyl chloride → 4-Methoxybenzenesulfonamide

HRID 326709

Reaktionsgleichung

Reaktionsgleichung von HRID 326709
[NH4+:1].[OH-].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][CH:6]=1>O1CCCC1>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH2:1])(=[O:13])=[O:12])=[CH:7][CH:6]=1

Komponenten

4

Edukt 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 14923Ammonium Hydroxide

Produkt 1

HCID 707894-Methoxybenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

25 ml of 25% NH4OH were added dropwise while cooling in an ice bath to a solution of 7.3 g of p-methoxybenzenesulfonyl chloride in 50 ml of tetrahydrofuran. Subsequently, the reaction mixture was stirred vigorously for 30 minutes at 70° C. (bath temperature). Thereafter, the tetrahydrofuran was distilled. The residue was extracted with ethyl acetate. There was obtained p-methoxybenzenesulfonamide which was converted into the potassium salt as described in Example 50.

Aufarbeitung

  1. distillationThereafter, the tetrahydrofuran was distilled
  2. extractionThe residue was extracted with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-951efbaa19c74b62ab9164d05a2e3923
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05270313

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