Water → HCID 19735046, Verbindung

HRID 326719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 326719
[C:1]([CH:3]([CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)[C:4]([O:6]CC)=[O:5])#[N:2].[OH-].[Na+].O>C(O)C>[C:1]([CH:3]([CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)[C:4]([OH:6])=[O:5])#[N:2]

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 19735035HCID 19735035, Verbindung

Produkt 1

HCID 19735046HCID 19735046, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethyl 2-cyano-3-(3-indolyl)propionate (350 mg, 1.45 mmol) (S. Masanori, et al., Heterocycles, 1981, 16: 941-9) was dissolved in ethanol (6 mL). 2N Sodium hydroxide solution (4 mL) was added and the reaction mixture was stirred at ambient temperature for 20 hours. Water (10 mL) was added and the ethanol was removed under reduced pressure. The pH of the aqueous solution was adjusted to approximately 1 with 6N hydrochloric acid solution and it was extracted with ethyl acetate. The ethyl acetate solution was concentrated in vacuo to give the title compound which was carried on to the next step without purification.

Aufarbeitung

  1. customthe ethanol was removed under reduced pressure
  2. extractionwas extracted with ethyl acetate
  3. concentrationThe ethyl acetate solution was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2c93d15d301a4b138cb05278f29b4e5f
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05270302

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