Acetaldehyde → HCID 19735971, Verbindung

HRID 326780Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 326780
[CH2:1]([O:8][C:9]([C:11]1[CH:19]=[CH:18][C:14]([C:15](Cl)=[O:16])=[CH:13][CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:20](=[O:22])[CH3:21].C(Cl)[Cl:24]>[Cl-].[Zn+2].[Cl-]>[CH2:1]([O:8][C:9]([C:11]1[CH:19]=[CH:18][C:14]([C:15]([O:22][CH:20]([Cl:24])[CH3:21])=[O:16])=[CH:13][CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 177AcetaldehydeHCID 6344DichloromethaneHCID 19735978Benzyl 4-(chlorocarbonyl)benzoate

Produkt 1

HCID 19735971HCID 19735971, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3007855ZincchlorideKatalysator

Versuchsvorschrift

Zinc chloride (524 mg) was fused in vacuo and, after cooling, treated with 4-(benzyloxycarbonyl)benzoyl chloride (21.48 g, 78.2 mmole). After 30 min., acetaldehyde (3.44 g, 78 mmole) was added at 0° C. The reaction mixture was stirred at room temperature for 30 min. and then diluted with CH2Cl2. The mixture was stirred for another 30 min. and then washed with water (3×). After drying with MgSO4, filtration, and concentration in vacuo, a green/brown solid was obtained that was chromatographed (25:75-CH2Cl2 :hexane) to give 7.65 (31%) of 1-chloroethyl 4-(benzyloxycarbonyl)benzoate as a white solid: mp 79°-82° C.; Anal. calcd for C17H15CIO4 ; C, 64.06; H, 4.74. Found: C, 63.88; H, 4.44. This chloroethyl ester (4.00 g, 12.5 mmole) was combined with the sodium salt of 3-[hydroxy-(2-thienyl)methylene]-6-chloro-5-fluoro- 2,3-dihydro-2-oxo-1H-indole-1-carboxamide (4.51 g, 12.5 mmole) and sodium iodide (644 mg, 4.3 mmole) in acetone (40 ml) and refluxed for 12 hr. The reaction mixture was filtered and the filtrate concentrated in vacuo. The orange/brown gum was chromatographed (25:75-EtOAc: hexane, then 1:99-EtOAc:CH2Cl2) to give 1.947 g (25%) of an orange foam: Anal. calcd. for C31H22ClFN2O7S·2/3H2O: C, 58.81; H, 3.72; N, 4.43. Found: C, 58.74; H, 3.38; N, 4.38.

Aufarbeitung

  1. temperatureafter cooling
  2. stirringThe mixture was stirred for another 30 min.
  3. washwashed with water (3×)
  4. dry with materialAfter drying with MgSO4, filtration, and concentration in vacuo
  5. customa green/brown solid was obtained
  6. customthat was chromatographed (25:75-CH2Cl2 :hexane)

Quellen und Nachweise

ORD-Eintrag
ord-fb868a24f62e4903924bd4b46ec9733f
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05270331

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