Bromine → 3-Methyl-2-(3-oxo-2,3-dihydro-1,2-benzothiazol-2-yl)butanoic acid

Reaktionsgleichung

C(C(NC(C1C=CC=CC=1S[S:19][C:20]1[CH:35]=[CH:34][CH:33]=[CH:32][C:21]=1[C:22]([NH:24][CH:25]([CH:29]([CH3:31])[CH3:30])[C:26]([OH:28])=[O:27])=[O:23])=O)CC(C)C)(O)=O.BrBr>>[CH3:30][CH:29]([CH3:31])[CH:25]([N:24]1[C:22](=[O:23])[C:21]2[CH:32]=[CH:33][CH:34]=[CH:35][C:20]=2[S:19]1)[C:26]([OH:28])=[O:27]

Komponenten

Edukt 2

HCID 24408Bromine

HCID 537625122-[2-[2-(1-Carboxy-3-methylbutyl carbamoyl)phenyldisulfanyl]benzoylamino)-3-methylbutanoic acid

Produkt 1

HCID 154107083-Methyl-2-(3-oxo-2,3-dihydro-1,2-benzothiazol-2-yl)butanoic acidAusbeute 0,1 %

Versuchsvorschrift

Following the procedure of Example 13, 6.0 g (13.6 mol) of 2-[2-[2-(1-carboxy-3-methylbutyl carbamoyl)phenyldisulfanyl]benzoylamino]-3-methylbutanoic acid was reacted with bromine to provide 2.25 g of the title compound, mp 166°-168° C.

Quellen und Nachweise

ORD-Eintrag: ord-c22db2c5c35e41f08e3017072fa1182e
Quelldatensatz: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05733921

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