Hydrochloric Acid → Benzanilide

HRID 326800

Reaktionsgleichung

Reaktionsgleichung von HRID 326800
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8](Cl)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[OH-].[Na+].Cl>O.CC(C)=O>[C:2]1([NH:1][C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 6115Aniline2×HCID 7412Benzoyl chloride2×HCID 14798Sodium Hydroxide2×

Produkt 1

HCID 7168Benzanilide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittel2×HCID 962WaterLösungsmittel

Versuchsvorschrift

N-phenylbenzamide (Structure II) is synthesized from aniline and benzoyl chloride using acetone as a reaction media and an aqueous solution of NaOH to neutralize the HCl generated. A 20 ml aqueous solution of NaOH (2.57 grams, 0.064 moles) and 6.0 grams (0.064 moles) of aniline are first added to a stirred 250 ml flask containing 75 ml of acetone. Benzoyl chloride (9.06 grams, 0.064 moles) is next added over a five minute period. This reaction mixture which now contains a white precipitate is stirred for 1.5 hours and then diluted with 50 ml of deionized water. This solution is next filtered and the filter cake obtained is sequentially washed with 50 ml of deionized water (two times) followed by 50 ml of methanol. The washed filter cake is recovered and DCS analysis of this product showed a sharp melting endotherm at 169° C. ##STR10##

Aufarbeitung

  1. customas a reaction media
  2. filtrationnext filtered
  3. customthe filter cake obtained
  4. washis sequentially washed with 50 ml of deionized water (two times)
  5. filtrationThe washed filter cake
  6. customis recovered
  7. customat 169° C.

Quellen und Nachweise

ORD-Eintrag
ord-767d3ca660a04ddbb47255484b2337e9
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05270406

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