Morpholine → 5-Ethanesulfonyl-2-morpholin-4-yl-benzoic acid

Reaktionsgleichung

CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29]([CH2:32][CH3:33])(=[O:31])=[O:30])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[NH:34]1[CH2:39][CH2:38][O:37][CH2:36][CH2:35]1>>[CH2:32]([S:29]([C:26]1[CH:27]=[CH:28][C:20]([N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH2:35]2)=[C:21]([CH:25]=1)[C:22]([OH:24])=[O:23])(=[O:31])=[O:30])[CH3:33]

Komponenten

Edukt 3

HCID 8083Morpholine

HCID 431409922-Chloro-5-(ethanesulfonyl)benzoic acid

HCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Produkt 1

HCID 597936685-Ethanesulfonyl-2-morpholin-4-yl-benzoic acidAusbeute 77 %

Versuchsvorschrift

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(ethane-2-sulfonyl)-benzoic acid and morpholine and obtained in 77% yield. MS (m/e): 298.2 (MH−, 100%).

Aufarbeitung

customobtained in 77% yield

Quellen und Nachweise

ORD-Eintrag: ord-02e9fd5a5761493db4bece9d68c0e2e3
Quelldatensatz: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07427612B2

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