Morpholine → 3-(4-(4-Acetyl-2-fluorophenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

Reaktionsgleichung

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[C:20]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:21]=[CH:22][C:23]=3Cl)=[O:17])[CH2:12][CH2:11]2)=[C:6]([F:29])[CH:5]=1)(=[O:3])[CH3:2].[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[C:20]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:21]=[CH:22][C:23]=3[N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)=[O:17])[CH2:12][CH2:11]2)=[C:6]([F:29])[CH:5]=1)(=[O:3])[CH3:2]

Komponenten

Edukt 2

HCID 8083Morpholine

HCID 368074103-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-benzenesulfonamide

Produkt 1

HCID 417727443-(4-(4-Acetyl-2-fluorophenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

Versuchsvorschrift

The title compound was prepared according to the procedure described for example 1 from 3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-benzenesulfonamide and morpholine (39%, yellow solid), MS (m/e): 489.4 (M−H, 100%)

Quellen und Nachweise

ORD-Eintrag: ord-809f4ee148ac4f1a83bce464687694a3
Quelldatensatz: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07427612B2

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