Oxalyl chloride → 1-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride

HRID 327423Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 327423
[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[N:4]=[C:3]1[C:10]([OH:12])=O.C(Cl)(=O)C([Cl:16])=O>C1COCC1>[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-:9])=[O:8])[N:4]=[C:3]1[C:10]([Cl:16])=[O:12]

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 120679981-Methyl-4-nitro-1H-imidazole-2-carboxylic acid

Produkt 1

HCID 191086291-Methyl-4-nitro-1H-imidazole-2-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 1-methyl-4-nitroimidazole-2-carboxylic acid (2.0 g, 0.012 mol) in dry THF (20 mL) was slowly added oxalyl chloride (6 mL). The solution was heated to reflux for 45 minutes, and the solvent and excess oxalyl chloride were removed under reduced pressure to give 1-methyl-4-nitroimidazole-2-carbonyl chloride as a yellow powder which was coevaporated with dry CH2Cl2 (15 mL).

Aufarbeitung

  1. temperatureThe solution was heated
  2. temperatureto reflux for 45 minutes
  3. customthe solvent and excess oxalyl chloride were removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d05f0e15c49f4f5eaa690a306ce1426a
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05273991

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