HCID 19108658, Verbindung → HCID 19108657, Verbindung

HRID 327424Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 327424
[CH3:1][N:2]([NH:4][C:5]([C:7]1[N:8]([CH3:15])[CH:9]=[C:10]([N+:12]([O-])=O)[N:11]=1)=[O:6])[CH3:3]>CO.[Pd]>[CH3:3][N:2]([NH:4][C:5]([C:7]1[N:8]([CH3:15])[CH:9]=[C:10]([NH2:12])[N:11]=1)=[O:6])[CH3:1]

Komponenten

4

Edukt 1

HCID 19108658HCID 19108658, Verbindung

Produkt 1

HCID 19108657HCID 19108657, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of N-(N',N'-dimethylamino)-1-methyl-4-nitroimidazole-2-carboxamide (2.01 g, 9.4 mmol) and 5% Pd on charcoal (0.8 g) in chilled methanol (100 mL) was purged of air and hydrogenated at room temperature and atmospheric pressure for 4 hours. The catalyst was removed by filtration and the solvent was evaporated under reduced pressure to give N-(N',N'-dimethylamino)-1-methyl-4-aminoimidazole-2-carboxamide as a glassy solid which is unstable and used directly in the next step.

Aufarbeitung

  1. customwas purged of air and hydrogenated at room temperature
  2. customThe catalyst was removed by filtration
  3. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-67b5adc0a58f430583acd561c3c1cb17
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05273991

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