HCID 19108632, Verbindung → HCID 19108635, Verbindung

HRID 327426Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 327426
[CH3:1][N:2]([NH:4][C:5]([C:7]1[N:8]([CH3:24])[CH:9]=[C:10]([NH:12][C:13]([C:15]2[N:16]([CH3:23])[CH:17]=[C:18]([N+:20]([O-])=O)[N:19]=2)=[O:14])[N:11]=1)=[O:6])[CH3:3]>CO.[Pd]>[CH3:3][N:2]([NH:4][C:5]([C:7]1[N:8]([CH3:24])[CH:9]=[C:10]([NH:12][C:13]([C:15]2[N:16]([CH3:23])[CH:17]=[C:18]([NH2:20])[N:19]=2)=[O:14])[N:11]=1)=[O:6])[CH3:1]

Komponenten

4

Edukt 1

HCID 19108632HCID 19108632, Verbindung

Produkt 1

HCID 19108635HCID 19108635, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of N-(N',N'-dimethylamino)-1-methyl-4-[1-methyl-4-nitroimidazole-2-carboxamido]-imidazole-2-carboxamide (0.50 g, 1.49 mmol) and 5% Pd on charcoal (0.2 g) in chilled methanol (20 mL) was purged of air and hydrogenated at room temperature for 6 hours. The catalyst was removed by filtration and the methanol evaporated under reduced pressure to give N-(N',N'-dimethylamino)-1-methyl-4-[1-methyl-4-aminoimidazole-2-carboxamido]-imidazole-2-carboxamide as an unstable yellow solid.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe methanol evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1c00c3cd90a04afcb0295d1632f920a7
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05273991

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