Dimethylformamide → 3,4,5-Trimethoxyphenylacetonitrile

HRID 327498

Reaktionsgleichung

Reaktionsgleichung von HRID 327498
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6]Cl.[C-]#N.[Na+].[CH3:18][N:19](C)C=O>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:6][C:18]#[N:19])[CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12]

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 8929Sodium CyanideHCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzene

Produkt 1

HCID 258873,4,5-Trimethoxyphenylacetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

3,4,5-trimethoxy benzyl chloride 7.0 g and sodium cyanide 6.3 g were dissolved into 50 ml of N,N-dimethylformamide and they were then stirred at 80° C. for 45 minutes. The temperature of the reactive liquid was then lowered down to the room temperature, 200 ml of water was added thereto and then extraction was made thrice by means of 100 ml of ethyl acetate.

Aufarbeitung

  1. additionwas added
  2. extractionextraction

Quellen und Nachweise

ORD-Eintrag
ord-952544069fad4375a8343463edfcc445
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05273985

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