Morpholine → Boc-Phe Morpholinamide

HRID 327793

Reaktionsgleichung

[N+](C1C=[CH:8][C:7]([O:10][C:11](=[O:28])[C@H:12]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=CC=1)([O-])=O.[NH:29]1CCOCC1>>[N:13]1([C:14]([NH2:29])=[O:16])[CH2:12][CH2:11][O:10][CH2:7][CH2:8]1.[C:17]([O:16][C:14]([NH:13][C@H:12]([C:11]([OH:28])=[O:10])[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:15])([CH3:20])([CH3:18])[CH3:19]

Komponenten

Edukt 2

HCID 8083Morpholine

HCID 111308Boc-Phe-ONp

Produkt 1

HCID 131717846Boc-Phe Morpholinamide

Versuchsvorschrift

N-tert-Butoxycarbonyl-L-phenylalanine morpholinoamide was prepared following the procedure of Example 25 Step (a) starting from N-tert-butoxycarbonyl-L-phenylalanine p-nitrophenyl ester and morpholine.

Quellen und Nachweise

ORD-Eintrag: ord-832d9e23564343f787423df8d5056e83
Quelldatensatz: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05274094

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