Benzoyl chloride → 4-Methoxybenzophenone

HRID 327852

Reaktionsgleichung

Reaktionsgleichung von HRID 327852
[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9](Cl)(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[Cl-].[Al+3].[Cl-].[Cl-]>CCCCCC>[CH3:8][O:7][C:1]1[CH:6]=[CH:5][C:4]([C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:16])=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 7412Benzoyl chlorideHCID 7519AnisoleHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 691464-Methoxybenzophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8058HexaneLösungsmittel

Versuchsvorschrift

Anisole (0.1 mole, 10.8 grams) and benzoyl chloride (0.1 mole, 14 grams) were dissolved in 200 milliliters of hexane and stirred at room temperature while 15 grams of anhydrous aluminum chloride were added slowly over a period of 15 minutes. The reaction mixture was stirred an additional 15 minutes and then the hexane decanted. The resulting viscous residue in the reaction flask was carefully hydrolyzed with 200 milliliters of a mixture of ice and dilute hydrochloric acid. The resulting organic fraction was taken up in dichloromethane and the resulting solution washed with water. Dichloromethane solvent was removed on a rotary evaporator leaving an oil product that solidified on standing. The solidified product was broken-up, washed with two 50 milliliters portions of pentane, and suction dried yielding 4-methoxybenzophenone.

Aufarbeitung

  1. additionwere added slowly over a period of 15 minutes
  2. customthe hexane decanted
  3. washthe resulting solution washed with water
  4. customDichloromethane solvent was removed on a rotary evaporator
  5. customleaving an oil product that
  6. washwashed with two 50 milliliters portions of pentane, and suction
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-01ef589c464545b7a41f11665b6a44da
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05274132

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