Hydrazine hydrate (1:1) → 8-Hydroxy-7-phenyl-2,3-dihydropyrido[3,4-d]pyridazine-1,4-dione

HRID 328322Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 328322
Cl.[OH:2][C:3]1[C:4]([C:20]([OH:22])=O)=[C:5]([C:15](OCC)=[O:16])[CH:6]=[N:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.O.[NH2:24][NH2:25]>C(O)C>[OH:2][C:3]1[C:4]2[C:20](=[O:22])[NH:25][NH:24][C:15](=[O:16])[C:5]=2[CH:6]=[N:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 131710706HCID 131710706, Verbindung

Produkt 1

HCID 123246328-Hydroxy-7-phenyl-2,3-dihydropyrido[3,4-d]pyridazine-1,4-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2 g. ethyl 5-hydroxy-6-phenylpyridine3,4-dicarboxylate. hydrochloride, 40 ml ethanol and 4 ml hydrazine hydrate was refluxed for 4 hours. After cooling, the pale yellow crystals were recovered by filtration, suspended in 20 ml of water and made acid with dilute hydrochloric acid. The crystals were recovered by filtration, rinsed with water and dried. The procedure provided 1.2 g of 8-hydroxy-7-phenylpyrido[3,4-d]pyridazine-1,4-(2H,3H)-dione, melting point: more than 300° C.

Aufarbeitung

  1. additionA mixture of 2 g
  2. temperatureAfter cooling
  3. filtrationthe pale yellow crystals were recovered by filtration
  4. filtrationThe crystals were recovered by filtration
  5. washrinsed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-1cffaf3e3bae4354b076dead8e515b99
Quelldatensatz
uspto-grants-1977_04
Patentnummer
US04017490

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