Ethyl 3-(2-benzoyl-4-chloroanilino)-3-oxopropanoate → Ethyl 2'-benzoyl-4'-chloro-mesoxalanilate 2-oxime

HRID 328494Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 328494
[N:1]([O-:3])=O.[Na+].[C:5]([C:13]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:14]=1[NH:15][C:16](=[O:23])[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(O)(=O)C>[C:5]([C:13]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:14]=1[NH:15][C:16](=[O:23])[C:17](=[N:1][OH:3])[C:18]([O:20][CH2:21][CH3:22])=[O:19])(=[O:12])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Komponenten

4

Edukt 2

HCID 21409980Ethyl 3-(2-benzoyl-4-chloroanilino)-3-oxopropanoateHCID 23668193Sodium Nitrite

Produkt 1

HCID 86733591Ethyl 2'-benzoyl-4'-chloro-mesoxalanilate 2-oxime

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 50 g. of sodium nitrite is added dropwise to a solution of 34.6 g. of ethyl 2'-benzoyl-4'-chloro-malonanilate in 250 ml. of glacial acetic acid. After 11/2 hours stirring at room temperature, the oxime crystallizes out and is filtered off by suction, washed with water and dried in vacuum. Ethyl 2'-benzoyl-4'-chloro-mesoxalanilate 2-oxime, m.p. 98°-105° is obtained.

Aufarbeitung

  1. customthe oxime crystallizes out
  2. filtrationis filtered off by suction
  3. washwashed with water
  4. customdried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2e141ab006cb45038a9401b978273219
Quelldatensatz
uspto-grants-1977_04
Patentnummer
US04017532

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