Sodium Hydroxide → HCID 12801675, Verbindung
Reaktionsgleichung
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:19]=[C:18]3[C:13]([C:14](=[O:27])[C:15]([C:22]([O:24]CC)=[O:23])=[CH:16][N:17]3[CH2:20][CH3:21])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>C(O)(=O)C>[CH2:20]([N:17]1[C:18]2[C:13](=[CH:12][CH:11]=[C:10]([N:7]3[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]3)[N:19]=2)[C:14](=[O:27])[C:15]([C:22]([OH:24])=[O:23])=[CH:16]1)[CH3:21]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 95 °C
Versuchsvorschrift
To 1.6 g of ethyl 7-(4-acetyl-1-piperazinyl)-1,4-dihydro-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylate was added 15 ml of a 10% aqueous solution of sodium hydroxide. The mixture was heated at 95° C for 1.5 hours, and neutralized, under cooling, with acetic acid to give a precipitate which was collected and recrystallized from water to yield 1.0 g of the product as colorless needles, m.p. 272° - 273° C.