Chloroacetyl chloride → N-benzyl-N-tert-butyl-2-chloroacetamide

HRID 328626

Reaktionsgleichung

Reaktionsgleichung von HRID 328626
[CH2:1]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].[Cl:15][CH2:16][C:17](Cl)=[O:18]>ClCCCl>[CH2:1]([N:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:17](=[O:18])[CH2:16][Cl:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6577Chloroacetyl chlorideHCID 14798Sodium HydroxideHCID 76908N-(1,1-Dimethylethyl)benzenemethanamine

Produkt 1

HCID 2386050N-benzyl-N-tert-butyl-2-chloroacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

To a stirred and cooled mixture of 33 parts of N-benzyl-N-tert.-butylamine in 60 parts of sodium hydroxide solution 20% and 160 parts of 1,2-dichloroethane are added dropwise 34 parts of 2-chloroacetyl chloride at a temperature between -5° and -10° C. Upon completion, stirring is continued at the same temperature for one hour. The reaction mixture is allowed to reach room temperature and the organic layer is separated, washed with water, dried and evaporated, yielding 43 parts of N-benzyl-N-tert.-butyl-2-chloroacetamide as a residue.

Aufarbeitung

  1. temperaturecooled
  2. stirringUpon completion, stirring
  3. customto reach room temperature
  4. customthe organic layer is separated
  5. washwashed with water
  6. customdried
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5f90d87b76b841d88b04a4c41097ad9d
Quelldatensatz
uspto-grants-1977_04
Patentnummer
US04017631

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