1-(Pyridin-3-yl)butane-1,3-dione → HCID 68117143, Verbindung

HRID 328709

Reaktionsgleichung

Reaktionsgleichung von HRID 328709
[NH2:1][CH2:2][CH:3]([OH:15])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH2:13][CH3:14].[C:16]([CH2:24][C:25](=O)[CH3:26])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=1>C(O)C.C(O)=O>[C:16]([CH:24]=[C:25]([NH:1][CH2:2][CH:3]([OH:15])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH2:13][CH3:14])[CH3:26])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=1

Komponenten

5

Edukt 2

HCID 3001601-(Pyridin-3-yl)butane-1,3-dioneHCID 1664239146415-57-0

Produkt 1

HCID 68117143HCID 68117143, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 284Formic AcidKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

4.2 g of (-)-1-amino-3-(o-ethoxyphenoxy)-propan-2-ol (laevo-rotatory) ##STR38## are dissolved in 30 ml of ethanol, 3.3 g of the nicotinoyl-acetone ##STR39## are then added and the mixture is heated for 4 hours under reflux, with addition of 1 drop of formic acid as the catalyst. The clear solution is cooled to room temperature and concentrated in a water pump vacuum. An oil is left, which solidifies after a short time. The solid product is recrystallised from toluene. (-)-1-(2-Nicotinoyl-1-methyl-vinylamino)-3-(o-ethoxyphenoxy)-propan-2-ol (laevo-rotatory) is thus obtained ##STR40##

Aufarbeitung

  1. temperaturethe mixture is heated for 4 hours
  2. concentrationconcentrated in a water pump vacuum
  3. waitAn oil is left
  4. customThe solid product is recrystallised from toluene

Quellen und Nachweise

ORD-Eintrag
ord-0bde44472cf54c498a95ba278c39efb1
Quelldatensatz
uspto-grants-1977_04
Patentnummer
US04018778

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