1-(5-Methoxy-2-nitro-phenyl)-piperidine → HCID 69307727, Verbindung

HRID 32888

Reaktionsgleichung

Reaktionsgleichung von HRID 32888
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:15]([O-])=O)=[C:7]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:8]=1>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH2:15])=[C:7]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:8]=1

Komponenten

4

Edukt 1

HCID 693104281-(5-Methoxy-2-nitro-phenyl)-piperidine

Produkt 1

HCID 69307727HCID 69307727, VerbindungAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1-(5-methoxy-2-nitro-phenyl)-piperidine (80 mg, 0.33 mmol, as prepared in the previous step) was stirred with 55 mg of 5% Pd—C in MeOH (4 mL) under H2 balloon pressure for 2 h. The reaction was filtered through Celite and concentrated in vacuo to afford 67 mg (98%) of the title compound as a reddish solid, which was used immediately without further purification. Mass spectrum (ESI, m/z): Calcd. for C12H18N2O, 207.1 (M+H), found 207.2.

Aufarbeitung

  1. filtrationThe reaction was filtered through Celite
  2. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e30b55c16b3344b4aaa2732f6de7ee42
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07427683B2

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