Phenol → 1-Phenoxy-2-benzyloxy-3-(iso-propylamino)-propane
Reaktionsgleichung
[CH:1]([N:4]1[CH2:7][CH:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:5]1)([CH3:3])[CH3:2].[C:16]1([OH:22])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[OH-].[K+]>CCOCC>[O:22]([CH2:5][CH:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:7][NH:4][CH:1]([CH3:2])[CH3:3])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 180 °C
Versuchsvorschrift
To a mixture of 6.2 parts of 1-(iso-propyl)-3-benzyloxyazetidine and 28 parts of phenol 1.5 parts of potassium hydroxide was added, and the mixture was heated at 180° C. for 6 hours. The reaction mixture was cooled and 100 parts of ether were added thereto. The excessive phenol was extracted with 2N-sodium hydroxide aqueous solution and removed. The remaining ether layer was washed in water and dried over anhydrous sodium sulfate. After distillation of ether, the residue was successively subjected to distillation to yield 7.6 parts of 1-phenoxy-2-benzyloxy-3-(iso-propylamino)-propane boiling at 158°-160° C. under 2 mm Hg. The yield was 85%. Results of infra-red spectrum analysis and nuclear magnetic resonance analysis of the product are as follows:
Aufarbeitung
- additionwas added
- temperatureThe reaction mixture was cooled
- extractionThe excessive phenol was extracted with 2N-sodium hydroxide aqueous solution
- customremoved
- washThe remaining ether layer was washed in water
- dry with materialdried over anhydrous sodium sulfate
- distillationAfter distillation of ether
- distillationthe residue was successively subjected to distillation
Quellen und Nachweise
- ORD-Eintrag
- ord-bf2230889b2349638c581d5f3756713c
- Quelldatensatz
- uspto-grants-1977_04
- Patentnummer
- US04018824
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