2-Naphthol → 1-(beta-Naphthoxy)-2-benzyloxy-3-(iso-propylamino)-propane
Reaktionsgleichung
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[OH:11].[CH:12]([N:15]1[CH2:18][CH:17]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:16]1)([CH3:14])[CH3:13].[OH-].[K+]>CCOCC>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:18][CH:17]([O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[CH2:16][NH:15][CH:12]([CH3:13])[CH3:14]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 180 °C
Versuchsvorschrift
A mixture of 17.3 parts of β-naphthol, 20.5 parts of 1-(iso-propyl)-3-benzyloxyazetidine, and 1.1 parts of potassium hydroxide was heated under nitrogen gas at 180° C. for 8 hours with agitation. The reaction mixture was cooled and dissolved in 100 parts of ether. The solution was washed with 50 parts of 2N-sodium hydroxide aqueous solution and dried over anhydrous sodium sulfate. Ether was distilled off and the residue was subjected to distillation to yield 29.3 parts of 1-(β-naphthoxy)-2-benzyloxy-3-(iso-propylamino)propane boiling at 185° -190° C. under 1 mm Hg. The yield was 84%. The results of infra-red spectrum analysis and nuclear magnetic resonance analysis of the product are as follows:
Aufarbeitung
- temperatureThe reaction mixture was cooled
- washThe solution was washed with 50 parts of 2N-sodium hydroxide aqueous solution
- dry with materialdried over anhydrous sodium sulfate
- distillationEther was distilled off
- distillationthe residue was subjected to distillation
Quellen und Nachweise
- ORD-Eintrag
- ord-2f48bb655e6745d28b97b9dbbda54b93
- Quelldatensatz
- uspto-grants-1977_04
- Patentnummer
- US04018824
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