Hydrogen Bromide → 3-[(2-Aminoethyl)thiomethyl]isoxazole hydrobromide

Reaktionsgleichung

Cl[CH2:2][C:3]1[CH:7]=[CH:6][O:5][N:4]=1.Cl.[NH2:9][CH2:10][CH2:11][SH:12].[BrH:13]>>[BrH:13].[NH2:9][CH2:10][CH2:11][S:12][CH2:2][C:3]1[CH:7]=[CH:6][O:5][N:4]=1

Komponenten

Edukt 3

HCID 260Hydrogen Bromide

HCID 9082Cysteamine Hydrochloride

HCID 49130253-(Chloromethyl)-1,2-oxazole

Produkt 1

HCID 205502033-[(2-Aminoethyl)thiomethyl]isoxazole hydrobromide

Versuchsvorschrift

A solution of 3-chloromethylisoxazole (5.8 g.) and cysteamine hydrochloride (6.25 g.) in aqueous hydrobromic acid (48%, 100 ml.) was heated under reflux for 6 hours. Concentration in the presence of water and subsequently n-propanol, followed by recrystallisation of the residue from isopropyl alcohol-ethanol afforded 3-[(2-aminoethyl)-thiomethyl]isoxazole hydrobromide, m.p. 131°-133°. (Found: Br, 33.6; S, 13.7. C6H10N2OS.HBr requires: Br, 33.4; S, 13.4).

Aufarbeitung

temperatureunder reflux for 6 hours
concentrationConcentration in the presence of water and subsequently n-propanol
customfollowed by recrystallisation of the residue from isopropyl alcohol-ethanol

Quellen und Nachweise

ORD-Eintrag: ord-072c02e041e1481bb01c440d5e568db3
Quelldatensatz: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04018931

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