Hydrochloric Acid → 3,4-Methylenedioxyphenylalanyl chloride hydrochloride

HRID 329171Notizen

Reaktionsgleichung

[CH2:1]1[O:15][C:14]2[CH:13]=[CH:12][C:5]([CH2:6][C@@H:7]([C:9](O)=[O:10])[NH2:8])=[CH:4][C:3]=2[O:2]1.Cl.P(Cl)(Cl)(Cl)(Cl)[Cl:18].Cl.C1(NCC([Cl:34])=O)C=CC=CC=1>>[ClH:18].[CH2:1]1[O:15][C:14]2[CH:13]=[CH:12][C:5]([CH2:6][C@@H:7]([C:9]([Cl:34])=[O:10])[NH2:8])=[CH:4][C:3]=2[O:2]1

Komponenten

Edukt 4

HCID 313Hydrochloric Acid

HCID 24819Phosphorus pentachloride

HCID 12918717(S)-2-Amino-3-(benzo[D][1,3]dioxol-5-YL)propanoic acid

HCID 13140662N-Phenylglycyl chloride--hydrogen chloride (1/1)

Produkt 1

HCID 867342163,4-Methylenedioxyphenylalanyl chloride hydrochloride

Versuchsvorschrift

The compound 3,4-methylenedioxyphenylalanine, Ber., 59, 2952 (1926), is treated with hydrogen chloride and phosphorous pentachloride in accordance with the procedure described by Hartcastle et al., J. Org. Chem., 31, 897 (1966) for the preparation of phenylglycyl chloride hydrochloride to yield 3,4-methylenedioxyphenylalanyl chloride hydrochloride.

Quellen und Nachweise

ORD-Eintrag: ord-2c6906adf7194110b7100c74188569f5
Quelldatensatz: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04020060

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