Benzaldehyde → Beta-Nitrostyrene

Temperatur

-18 °C

Benzaldehyde (10.0 g, 94.2 mmol) and nitromethane (5.1 mL, 94.2 mmol) were dissolved in MeOH, the solution was cooled to -18° C., and NaOH (3.9 g, 98.9 mmol) in aqueous solution (80 mL) was added while maintaining the temperature below -10° C. The mixture was stirred at 0° C. for 2 hours, then stored at 5° C. overnight. The solution was then poured into stirring acid (200 mL conc. HCl/300 mL H2O). The precipitate was collected, washed, and recrystallized from EtOH to afford the title compound as light orange needles (5.15 g, 37%).

1. temperaturewhile maintaining the temperature below -10° C
2. waitstored at 5° C. overnight
3. additionThe solution was then poured
4. customThe precipitate was collected
5. washwashed
6. customrecrystallized from EtOH

ORD-Eintrag

ord-e4c5a915e9a24293aae0af7d3e5b3bcb

Quelldatensatz

uspto-grants-1998_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05733912