Diisopropylethylamine → HCID 86727989, Verbindung

HRID 330764Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 330764
[Br:1][C:2]1(F)[CH:7]=[CH:6][CH:5]=[CH:4][NH:3]1.Cl.[F:10][CH:11]([F:15])[CH2:12][NH:13][CH3:14].CCN(C(C)C)C(C)C>>[Br:1][C:2]1[N:3]=[C:4]([N:13]([CH2:12][CH:11]([F:15])[F:10])[CH3:14])[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 81531DiisopropylethylamineHCID 457923922,2-Difluoro-N-methylethan-1-amine--hydrogen chloride (1/1)HCID 67998121HCID 67998121, Verbindung

Produkt 1

HCID 86727989HCID 86727989, Verbindung

Versuchsvorschrift

88.0 mg (0.50 mmol) 2-bromo-2-fluoropyridine, 78.9 mg (0.60 mmol) (2,2-difluoro-ethyl)-methyl-amine hydrochloride and 0.17 mL (1.00 mmol) DIPEA are stirred at 90° C. over night. The reaction is quenched by the addition of water and extracted with DCM. The combined org. layers are dried over MgSO4, filtered and the solvent is removend in vacuo.

Aufarbeitung

  1. customThe reaction is quenched by the addition of water
  2. extractionextracted with DCM
  3. dry with materiallayers are dried over MgSO4
  4. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-fa724f70c7c0437fb9c2c24912c397c4
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877741B2

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