Methanol → Methyl 3-(5-methyl-1,2,4-oxadiazol-3-YL)benzoate

HRID 330794Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 330794
S(=O)(=O)(O)O.[CH3:6][C:7]1[O:11][N:10]=[C:9]([C:12]2[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=2)[C:15]([OH:17])=[O:16])[N:8]=1.O.[CH3:22]O>>[CH3:6][C:7]1[O:11][N:10]=[C:9]([C:12]2[CH:13]=[C:14]([CH:18]=[CH:19][CH:20]=2)[C:15]([O:17][CH3:22])=[O:16])[N:8]=1

Komponenten

5

Edukt 4

HCID 887MethanolHCID 962WaterHCID 1118Sulfuric AcidHCID 71278183-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoic acid

Produkt 1

HCID 53429639Methyl 3-(5-methyl-1,2,4-oxadiazol-3-YL)benzoate

Versuchsvorschrift

7.83 ml (147 mmol) of concentrated sulfuric acid are added to a suspension of 30.0 g (147 mmol) of 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoic acid in 150 ml of methanol, and the mixture is heated at the boil for 18 hours. The reaction mixture is cooled in an ice bath, water is added, the mixture is filtered off with suction and washed well with water: methyl 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoate as colourless crystals; m.p. 81° C., ESI 219 (M+H), HPLC: Rt.=2.65 min (method A).

Aufarbeitung

  1. temperaturethe mixture is heated at the boil for 18 hours
  2. temperatureThe reaction mixture is cooled in an ice bath
  3. filtrationthe mixture is filtered off with suction
  4. washwashed well with water
  5. custom=2.65 min (method A)

Quellen und Nachweise

ORD-Eintrag
ord-9e97ec0013794d7495789bd38f7c513f
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877751B2

Notizen zur Reaktion

Wird geladen…