Water → 3-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one

HRID 330800Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 330800
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9](=[O:11])[NH:8][C:7]=2[CH:12]=1.Cl.Cl[CH2:17][C:18]1[CH:19]=[C:20]([C:24]2[N:29]=[CH:28][C:27]([O:30][CH2:31][CH2:32][N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)=[CH:26][N:25]=2)[CH:21]=[CH:22][CH:23]=1.C(=O)([O-])[O-].[K+].[K+].O>C(#N)C>[N:33]1([CH2:32][CH2:31][O:30][C:27]2[CH:28]=[N:29][C:24]([C:20]3[CH:19]=[C:18]([CH:23]=[CH:22][CH:21]=3)[CH2:17][N:8]3[C:7]4[CH:12]=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=[CH:5][C:6]=4[S:10][C:9]3=[O:11])=[N:25][CH:26]=2)[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 132273405-(Trifluoromethyl)benzo[d]thiazol-2(3H)-oneHCID 669855014-{2-[2-(3-Chloromethylphenyl)pyrimidin-5-yloxy]ethyl}morpholine hydrochloride

Produkt 1

HCID 467007713-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A suspension of 89 mg (0.405 mmol) of 5-trifluoromethyl-3H-benzothiazol-2-one, 150 mg (0.405 mmol) of 4-{2-[2-(3-chloromethylphenyl)pyrimidin-5-yl-oxy]ethyl}morpholine hydrochloride and 286 mg (2.02 mmol) of potassium carbonate in 8 ml of acetonitrile are stirred at 70° C. for 5 days. 30 ml of water are added to the reaction mixture, with a precipitate slowly forming. The precipitate is filtered off with suction, washed with water and dried.

Aufarbeitung

  1. customslowly forming
  2. filtrationThe precipitate is filtered off with suction
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d6e890e927a2402ab0aae87c0d87fe88
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877751B2

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