Methanesulfonyl chloride → 2-(2-Fluorophenyl)ethyl methanesulfonate

HRID 331238

Reaktionsgleichung

Reaktionsgleichung von HRID 331238
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][OH:6].[CH3:11][S:12](Cl)(=[O:14])=[O:13]>C(N(CC)CC)C.C(Cl)Cl>[CH3:11][S:12]([O:6][CH2:5][CH2:4][C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[F:1])(=[O:14])=[O:13]

Komponenten

5

Edukt 2

HCID 31297Methanesulfonyl chlorideHCID 27332962-(2-Fluorophenyl)ethan-1-ol

Produkt 1

HCID 151245352-(2-Fluorophenyl)ethyl methanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

To a solution of 2-fluorophenethylalcohol (25.0 g) in triethylamine (37.5 ml) and methylene chloride (250 ml) was added dropwise methanesulfonyl chloride (16.7 ml) under ice-cooling, and the mixture was stirred for 30 min. The reaction mixture was warmed to room temperature, washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give 2-(2-fluorophenyl)ethyl methanesulfonate.

Aufarbeitung

  1. temperaturecooling
  2. washwashed with water and saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-c1a992d32f7e4db4abea21507bf12076
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877779B2

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