Sodium borohydride → [3-(3-Chloro-phenoxy)-4-methoxy-phenyl]-methanol

HRID 332575

Reaktionsgleichung

Reaktionsgleichung von HRID 332575
[Cl:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=1[O:14][CH3:15])[CH:9]=[O:10].[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[CH:7]=[C:8]([CH2:9][OH:10])[CH:11]=[CH:12][C:13]=1[O:14][CH3:15]

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 577011293-(3-Chloro-phenoxy)-4-methoxy-benzaldehyde

Produkt 1

HCID 57701122[3-(3-Chloro-phenoxy)-4-methoxy-phenyl]-methanolAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 3-(3-chloro-phenoxy)-4-methoxy-benzaldehyde (12) (393 mg, 1.5 mmol) in methanol (5 ml) was added sodium borohydride (300 mg, 7 mmol) at 0° C. The reaction mixture was stirred at room temperature for 16 h. The mixture was poured into ice-water, extracted with ethyl acetate, washed with water and brine, and dried over Na2SO4. The solvent was removed under vacuum to yield 330 mg (85% yield) of compound (13).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washwashed with water and brine
  3. dry with materialdried over Na2SO4
  4. customThe solvent was removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-dc4d906e03ec4a2cbd4c288def7a4b6f
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877816B2

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