Hydrochloric Acid → 7a-(5-Bromo-6-fluoro-3-pyridinyl)-hexahydro-1h-pyrrolizine hydrochloride salt

HRID 3326Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 3326
[Br:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:16][CH2:15][CH2:14][N:13]2[CH2:12][CH2:11][CH2:10]3)[CH:5]=[N:6][C:7]=1[F:8].[ClH:17]>CCOCC>[ClH:17].[Br:1][C:2]1[CH:3]=[C:4]([C:9]23[CH2:16][CH2:15][CH2:14][N:13]2[CH2:12][CH2:11][CH2:10]3)[CH:5]=[N:6][C:7]=1[F:8]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 189347337a-(5-bromo-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

Produkt 1

HCID 189347817a-(5-Bromo-6-fluoro-3-pyridinyl)-hexahydro-1h-pyrrolizine hydrochloride saltAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

7a-(5-bromo-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was triturated with Et2O and dried to afford the title compound as a white powder (59 mg, 87%): mp 213°-215° C.; 1H NMR D2O, 300 MHz) δ2.15-2.49 (m, 6H), 2.56-2.65 (m, 2H), 3.34-3.42 (m, 2H), 3.78-3.87 (m, 2H), 8.31 (dd, J=2.4, 1.0 Hz, 1H), 8.38 (dd, J=7.8, 2.4 Hz, 1H); MS (CI/NH3) m/z: 285/287 (M+H)+; MS (CI/NH3): m/z 285/287 (M+H+). Anal. Calcd for C12H14BrFN2.HCl: C, 44.81; H, 4.70; N, 8.71. Found: C, 45.04; H, 4.25; N, 8.48.

Aufarbeitung

  1. customThe solvent was removed
  2. customthe solid was triturated with Et2O
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a8c5c25f4fb846a89628f7a3b1c115e3
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05733912

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